Infectious Diseases in Obstetrics and Gynecology

Infectious Diseases in Obstetrics and Gynecology / 2000 / Article

Open Access

Volume 8 |Article ID 256309 |

Sangnya R. Patel, Wilhelmine Wiese, Sanjay C. Patel, Christopher Ohl, James C. Byrd, Carlos A. Estrada, "Systematic Review of Diagnostic Tests for Vaginal Trichomoniasis", Infectious Diseases in Obstetrics and Gynecology, vol. 8, Article ID 256309, 10 pages, 2000.

Systematic Review of Diagnostic Tests for Vaginal Trichomoniasis

Received31 Mar 2000
Accepted28 Aug 2000


Objective: To review critically and to summarize the evidence of diagnostic tests and culture media for the diagnosis of Trichomonas vaginitis.Methods: We performed a systematic review of literature indexed in MEDLINE of studies that used Trichomonas culture as the reference standard (9,882 patients, 35 studies). Level I studies (5,047 patients, 13 studies) fulfilled at least two of three criteria: 1) consecutive patients were evaluated prospectively, 2) decision to culture was not influenced by test results, and 3) there was independent and blind comparison to culture.Results: The sensitivity of the polymerase chain reaction technique (PCR) was 95% (95% CI 91% to 99%), and the specificity was 98% (95% CI 96% to 100%). One study was classified as Level I evidence (52 patients). The sensitivity of the enzyme-linked immunosorbent assay was 82% (95% CI 74% to 90%), and the specificity was 73% (95% CI 35% to 100%). The sensitivity of the direct fluorescence antibody was 85% (95% CI 79% to 90%), and the specificity was 99% (95% CI 98% to 100%). Sensitivities of culture media were 95% for Diamond's, 96% for Hollander, and 95% for CPLM.Conclusions: The sensitivity and specificity of tests to diagnose trichomoniasis vary widely. Infect. Dis. Obstet. Gynecol. 8:248–257, 2000.

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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