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Infectious Diseases in Obstetrics and Gynecology
Volume 9, Issue 4, Pages 239-244

The Inhibitory Effect of Clindamycin on Lactobacillus in vitro

1Department of Obstetrics and Gynecology, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, IL, USA
2Department of Obstetrics, Gynecology and Reproductive Medicine, University of Texas Houston Health Science Center, and The Woman’s Hospital of Texas, Houston, TX, USA

Received 18 June 2001; Accepted 2 October 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp.

Methods: Concentrations of clindamycin ranging from 1.95–20 000 mg/ml were studied for their effect on the growth of six strains of Lactobacillus .

Results: Clindamycin concentrations between 1.95–31.25 mg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 mg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1000 mg/ml.

Conclusion: High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus .