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Infectious Diseases in Obstetrics and Gynecology
Volume 12, Issue 1, Pages 23-26

Antenatal Diagnosis of Intrauterine Infection With Coxsackievirus B3 Associated With Live Birth

1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Ottawa, The Ottawa Hospital, Ottawa, Ontario K1H 8L6, Canada
2Division of Neonatology, Department of Pediatrics, The Children’s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
3Division of Microbiology, Department of Pathology and Laboratory Medicine, University of Ottawa, The Ottawa Hospital, Ottawa, Ontario, Canada

Received 21 July 2003; Accepted 10 December 2003

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: Prior reported cases of stillbirth and neonates infected with enteroviruses suggest transplacental infection. We present a case of fetal infection with coxsackievirus B3, diagnosed antenatally and resulting in live birth.

Case: A pregnant woman presented at 26 weeks with fetal tachycardia and non-immune hydrops fetalis. Coxsackievirus B3 was cultured from amniotic fluid. Maternal antibody to coxsackievirus B3 was positive at 1: 512. At 32 weeks, the fetus deteriorated and was delivered. Cord blood antibody to coxsackievirus B3 was positive at a higher titer. Following neonatal death, brain and placental tissues were positive for enterovirus ribonucleic acid by polymerase chain reaction.

Conclusion: Intrauterine infection by enteroviruses should be considered in the differential diagnosis of nonimmune hydrops fetalis. Antenatal diagnosis of coxsackievirus B3 infection is associated with poor outcome.