Effect of Bacterial Endotoxins on Superovulated Mouse Embryos In Vivo: Is CSF-1 Involved in Endotoxin-Induced Pregnancy Loss?

Jaiswal, Yogesh Kumar; Chaturvedi, Madan Mohan; Deb, Kaushik

doi:https://doi.org/10.1155/IDOG/2006/32050

Infectious Diseases in Obstetrics and Gynecology

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Clinical Study | Open Access

Volume 2006 | Article ID 032050 | https://doi.org/10.1155/IDOG/2006/32050

Effect of Bacterial Endotoxins on Superovulated Mouse Embryos In Vivo: Is CSF-1 Involved in Endotoxin-Induced Pregnancy Loss?

Yogesh Kumar Jaiswal,¹Madan Mohan Chaturvedi,²and Kaushik Deb¹

Received17 May 2006

Accepted17 Aug 2006

Published02 Oct 2006

Abstract

Mammalian embryonic development is regulated by several cytokines and growth factors from embryonic or maternal origins. Since CSF-1 plays important role in embryonic development and implantation, we investigated its role in gram-negative bacterial LPS-induced implantation failure. The effect of LPS on normal (nonsuperovulated) and superovulated in vivo-produced embryos was assessed by signs of morphological degeneration. A significantly similar number of morphologically degenerated embryos recovered from both nonsuperovulated and superovulated LPS treated animals on day 2.5 of pregnancy onwards were morphologically and developmentally abnormal as compared to their respective controls (P < .001. Normal CSF-1 expression level and pattern were also altered through the preimplantation period in the mouse embryos and uterine horns after LPS treatment. This deviation from the normal pattern and level of CSF-1 expression in the preimplantation embryos and uterine tissues suggest a role for CSF-1 in LPS-induced implantation failure.

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Copyright © 2006 Yogesh Kumar Jaiswal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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