<em>Helicobacter pylori</em> Seropositivity and Stool Antigen in Patients With Hyperemesis Gravidarum

Karadeniz, R. Sinan; Ozdegirmenci, Ozlem; Altay, M. Metin; Solaroglu, Ayse; Dilbaz, Serdar; Hızel, Nedret; Haberal, Ali

doi:https://doi.org/10.1155/IDOG/2006/73073

Infectious Diseases in Obstetrics and Gynecology

On this page

Abstract References Copyright Related Articles

Clinical Study | Open Access

Volume 2006 | Article ID 073073 | https://doi.org/10.1155/IDOG/2006/73073

Helicobacter pylori Seropositivity and Stool Antigen in Patients With Hyperemesis Gravidarum

R. Sinan Karadeniz,¹Ozlem Ozdegirmenci,¹M. Metin Altay,¹Ayse Solaroglu,¹Serdar Dilbaz,¹Nedret Hızel,¹and Ali Haberal¹

Received28 Apr 2005

Revised30 Apr 2005

Accepted08 Dec 2005

Published22 Feb 2006

Abstract

The objective of this paper is to investigate whether Helicobacter pylori is an etiologic factor in hyperemesis gravidarum. Thirty one patients with hyperemesis gravidarum and twenty nine pregnant controls without hyperemesis gravidarum were included in this prospective study. All pregnant women were examined both for Helicobacter pylori serum immunoglobulin G antibodies (HpIgG Ab), showing chronic infection, and Helicobacter pylori stool antigens (HpSA), showing active gastrointestinal colonization. Chi-square and Student t tests were used accordingly for statistical analysis. Helicobacter pylori seropositivity was 67.7% in the patients with hyperemesis gravidarum and 79.3% in the control group (χ2=1.02,P=.31). HpSA was detected in 22.6% of patients with hyperemesis gravidarum, whereas 6.9% of patients in the control group. The difference was not statistically significant (χ2=2.89,P=.08). In this study, no relation was found between Helicobacter pylori and hyperemesis gravidarum. The low social status of women in both groups could be one of the reasons for the high prevalence of Hp infection.

References

J D Quinla and D A Hill, “Nausea and vomiting of pregnancy,” American Family Physician, vol. 68, no. 1, pp. 121–128, 2003.
View at: Google Scholar
F G Cunningham, P C MacDonald, N F Gant et al., Williams Obstetrics, Appleton & Lange, Stamford, Conn, 1997.
View at: Google Scholar
N K Kuşcu and F Koyuncu, “Hyperemesis gravidarum: current concepts and management,” Postgraduate Medical Journal, vol. 78, no. 916, pp. 76–79, 2002.
View at: Google Scholar
P Frigo, C Lang, K Reisenberger, H Kolbl, and A M Hirschl, “Hyperemesis gravidarum associated with Helicobacter pylori seropositivity,” Obstetrics & Gynecology, vol. 91, no. 4, pp. 615–617, 1998.
View at: Google Scholar
I Koçak, Y Akcan, C Üstün, C Demirel, L Cengiz, and F F Yanik, “Helicobacter pylori seropositivity in patients with hyperemesis gravidarum,” International Journal of Gynecology & Obstetrics, vol. 66, no. 3, pp. 251–254, 1999.
View at: Google Scholar
T Bagis, Y Gumurdulu, F Kayaselcuk, E S Yilmaz, E Killicadag, and E Tarim, “Endoscopy in hyperemesis gravidarum and Helicobacter pylori infection,” International Journal of Gynecology & Obstetrics, vol. 79, no. 2, pp. 105–109, 2002.
View at: Google Scholar
T Kazerooni, M Taallom, and A A Ghaderi, “Helicobacter pylori seropositivity in patients with hyperemesis gravidarum,” International Journal of Gynecology & Obstetrics, vol. 79, no. 3, pp. 217–220, 2002.
View at: Google Scholar
G F Jacobson, A M Autry, T L Somer-Shely, K L Pieper, and R S Kirby, “Helicobacter pylori seropositivity and hyperemesis gravidarum,” The Journal of Reproductive Medicine, vol. 48, no. 8, pp. 578–582, 2003.
View at: Google Scholar
B Berker, F Soylemez, S D Cengiz, and S K Kose, “Serologic assay of Helicobacter pylori infection. Is it useful in hyperemesis gravidarum?,” The Journal of Reproductive Medicine, vol. 48, no. 10, pp. 809–812, 2003.
View at: Google Scholar
B J Marshall and J R Warren, “Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration,” The Lancet, vol. 323, no. 8390, pp. 1311–1315, 1984.
View at: Google Scholar
J Versalovic, “Helicobacter pylori. Pathology and diagnostic strategies,” American Journal of Clinical Pathology, vol. 119, no. 3, pp. 403–412, 2003.
View at: Google Scholar
A K Adiloglu, C Nazli, B Cicioglu-Aridogan, O Kinay, R Can, and O Ergene, “Gastroduodenal Helicobacter pylori infection diagnosed by Helicobacter pylori stool antigen is related to atherosclerosis,” Acta Cardiologica, vol. 58, no. 4, pp. 335–339, 2003.
View at: Google Scholar
N Ossei-Gerning, P Moayyedi, S Smith et al., “Helicobacter pylori infection is related to atheroma in patients undergoing coronary angiography,” Cardiovascular Research, vol. 35, no. 1, pp. 120–124, 1997.
View at: Google Scholar
V Pasceri, G Cammarota, G Patti et al., “Association of virulent Helicobacter pylori strains with ischemic heart disease,” Circulation, vol. 97, no. 17, pp. 1675–1679, 1998.
View at: Google Scholar
R Pellicano, M G Mazzarello, S Morelloni et al., “Acute myocardial infarction and Helicobacter pylori seropositivity,” International Journal of Clinical & Laboratory Research, vol. 29, no. 4, pp. 141–144, 1999.
View at: Google Scholar
S Hayakawa, N Nakajima, M Karasaki-Suzuki et al., “Frequent presence of Helicobacter pylori genome in the saliva of patients with hyperemesis gravidarum,” American Journal of Perinatology, vol. 17, no. 5, pp. 243–247, 2000.
View at: Google Scholar
A Morris and G Nicholson, “Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH,” The American Journal of Gastroenterology, vol. 82, no. 3, pp. 192–199, 1987.
View at: Google Scholar
N Vakil, D Rhew, A Soll, and J J Ofman, “The cost-effectiveness of diagnostic testing strategies for Helicobacter pylori,” The American Journal of Gastroenterology, vol. 95, no. 7, pp. 1691–1698, 2000.
View at: Google Scholar
D Vaira, P Malfertheiner, F Megraud et al., “Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. HpSA European study grou{p},” The Lancet, vol. 354, no. 9172, pp. 30–33, 1999.
View at: Google Scholar
Ç Karaca, N Güler, A Yazar, H Çamlica, K Demir, and G Yildirim, “Is lower socio-economic status a risk factor for Helicobacter pylori infection in pregnant women with hyperemesis gravidarum?,” The Turkish Journal of Gastroenterology, vol. 15, no. 2, pp. 86–89, 2004.
View at: Google Scholar

Copyright

Copyright © 2006 R. Sinan Karadeniz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PDF Download Citation Order printed copies

Views

436

Downloads

1271

Citations