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Infectious Diseases in Obstetrics and Gynecology
Volume 2007 (2007), Article ID 24816, 6 pages
Clinical Study

High Titers of Chlamydia trachomatis Antibodies in Brazilian Women with Tubal Occlusion or Previous Ectopic Pregnancy

1Department of Microbiology, Immunology, Parasitology, and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua Delenda Resende de Mello S/N, 74605-050 Goiânia, Goiás, Brazil
2Division of Adolescent Medicine, Department of Pediatrics, Faculty of Medicine, Federal University of Goiás, Setor Universitário, 74233-180 Goiânia, Goiás, Brazil
3Department of Statistics, Federal University of Minas Gerais, Rua Juiz de Fora 801, 30180-060 Belo Horizonte, Minas Gerais, Brazil
4Department of Gynecology and Obstetrics, Faculty of Medicine, Federal University of Goiás, Setor Universitário, 74233-180 Goiânia, Goiás, Brazil

Received 5 January 2007; Accepted 9 March 2007

Copyright © 2007 A. C. S. Machado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate serum chlamydia antibody titers (CATs) in tubal occlusion or previous ectopic pregnancy and the associated risk factors. Methods. The study population consisted of 55 women wih tubal damage and 55 parous women. CAT was measured using the whole-cell inclusion immunofluorescence test and cervical chlamydial DNA detected by PCR. Odds ratios were calculated to assess variables associated with C. trachomatis infection. Results. The prevalence of chlamydial antibodies and antibody titers in women with tubal occlusion or previous ectopic pregnancy was significantly higher (P<.01) than in parous women. Stepwise logistic regression analysis showed that chlamydia IgG antibodies were associated with tubal damage and with a larger number of lifetime sexual partners. Conclusions. Chlamydia antibody titers were associated with tubal occlusion, prior ectopic pregnancy, and with sexual behavior, suggesting that a chlamydia infection was the major contributor to the tubal damage in these women.