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Infectious Diseases in Obstetrics and Gynecology
Volume 2007, Article ID 34763, 3 pages
Case Report

Xanthogranulomatous Endometritis: A Challenging Imitator of Endometrial Carcinoma

1Department of Pathology, School of Medicine, Yeditepe University, Istanbul 34755, Turkey
2Department of Pathology, School of Medicine, Hacettepe University, Ankara 06100, Turkey
3Department of Obstetrics and Gynecology, School of Medicine, Hacettepe University, Ankara 06100, Turkey

Received 22 January 2007; Accepted 9 March 2007

Copyright © 2007 A. Işın Doğan-Ekici et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Xanthogranulomatous inflammation is a distinguished histopathological entity affecting several organs, predominantly the kidney and gallbladder. So far, only a small number of cases of xanthogranulomatous inflammation occurring in female genital tract have been described, most frequently affecting the endometrium and histologically characterized by replacement of endometrium by xanthogranulomatous inflammation composed of abundant foamy histiocytes, siderophages, giant cells, fibrosis, calcification and accompanying polymorphonuclear leucocytes, plasma cells and lymphocytes of polyclonal origin. We present a case of a 69-year-old female complained of post menopausal bleeding and weight loss. Clinical preliminary diagnoses were endometrial carcinoma or hyperplasia and ultrasound was supposed to be endometrial malignancy, hyperplasia or pyometra by radiologist. Histopathological examination of uterus revealed xanthogranulomatous endometritis. Since xanthogranulomatous endometritis may mimic endometrial malignancy clinically and pathologically as a result of the replacement of the endometrium and occasionally invasion of the myometrium by friable yellowish tissue composed of histiocytes, knowledge of this unusual inflammatory disease is needed for both clinicians and pathologists.