Detection of Fastidious Vaginal Bacteria in Women with HIV Infection and Bacterial Vaginosis

Table 1

Characteristics of the study population (N = 51^§).

	BV+(𝑁=24)	BV−(𝑁=27)	𝑃 value
Age	35.7 ± 8.6	38.2 ± 6.5	.23
Race
White	11 (46)	9 (33)	.83
African American	8 (33)	11 (41)
Hispanic	5 (21)	7 (26)
(2 missing)
Time since HIV diagnosis	7.4 ± 4.8	6.8 ± 4.0	.59
On ART	9 (38)	13 (46)	.42
CD4 Count (median, IQR) cells/mL	393 (246–582)	437 (209–619)	.74
Plasma viral load (median, IQR) copies/mL	3250 (800–44,500)	4800 (320–41,000)	>.99
Vaginal fluid cells (cells/cc)
Nucleated cells	961 ± 1296	752 ± 1034	.53
RBCs	39 ± 41	676 ± 2458	.21
Monocytes	2.9 ± 5.4	0.2 ± 0.6	.012
Lymphocytes	0.8 ± 1.6	0.5 ± 1.3	.50
Eosinophils	1.2 ± 1.8	0.3 ± 1.0	.04
Log-transformed bacterial 16S rDNA copies/mL (mean ± SD)
Lactobacillus genus	6.93 ± 1.74	6.71 ± 2.08	.69
Lactobacillus crispatus	2.36 ± 3.05	2.43 ± 3.30	.94
Gardnerella vaginalis	7.21 ± 1.82	3.70 ± 3.04	<.001
Megasphaera	3.56 ± 3.66	0.56 ± 1.71	<.001
Leptotrichia/Sneathia	5.82 ± 3.59	2.12 ± 3.23	<.001
BVAB1	2.06 ± 3.51	0.50 ± 1.85	.045
BVAB2	4.22 ± 3.61	0.48 ± 1.50	<.001
BVAB3	2.38 ± 3.15	0.50 ± 1.50	.007

§For individuals who contributed more than one sample, only data from the first visit are included in this table. ∗Tests are chi-square for categorical variables, and 𝑡-test or Mann-Whitney for continuous variables. Data presented as mean ± SD for continuous variables or 𝑛(%) for categorical variables unless otherwise noted.