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Infectious Diseases in Obstetrics and Gynecology
Volume 2009, Article ID 810596, 6 pages
http://dx.doi.org/10.1155/2009/810596
Clinical Study

Epidemiology of HPV in HIV-Positive and HIV-Negative Fertile Women in Cameroon, West Africa

1Division of Infectious Diseases, Department of Internal Medicine, Meharry Medical College, 1005 Dr. DB Todd Jr Boulevard, Nashville, TN 37208, USA
2Department of Obstetrics and Gynecology, Sanford School of Medicine, The University of South Dakota, Vermillion, Sioux Falls, SD 57105, USA
3Clinical Research Division, Avera Research Institute, Sioux Falls, SD 57105, USA
4Cameroon Baptist Convention Health Board, Bamenda, Cameroon

Received 3 April 2009; Accepted 14 December 2009

Academic Editor: Faustino R. Pérez-López

Copyright © 2009 Andrew J. Desruisseau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. HPV types vary by country and HIV status. There are no data on the prevalent HPV genotypes from Cameroon. Methods. We conducted a cross-sectional, observational study on 65 Cameroonian women. Samples were sent for HPV genotyping and Thin Prep analyses. Results. 41 out of 61 samples tested (67.2%) had HPV subtypes detected. The most common high risk types encountered were: 45 (24.6%) and 58 (21.5%). HIV-positive women were more likely to test positive for any HPV ( ), have more than one HPV subtype ( ), and to test positive for the high risk subtypes ( ). Of those with high risk HPV, HIV-positive women were more likely to have Thin Prep abnormalities than HIV-negative women ( ). Conclusions. Oncogenic HPV subtypes 45 and 58 were more prevalent than those subtypes carried in the quadrivalent vaccine. Further studies are needed to assess whether the current vaccine will be effective in this region.