Evidence for Vertical Transmission of HPV from Mothers to Infants

Table 2

HPV types and frequencies in mothers and newborns (𝑁=333).

	Mother				Newborn
	DNA			Serum^3	DNA			Serum^3
	Cervical	Oral^5	Cervical/Oral		Genital	Oral	Genital/Oral
HPV status	𝑁 (%)	𝑁 (%)	𝑁 (%)	𝑁 (%)	𝑁 (%)	𝑁 (%)	𝑁 (%)	𝑁 (%)
HPV+^1	93 (27.9)	10 (3.0)	99 (29.7)	108 (32.4)	2 (0.6)	3 (0.9)	5 (1.5)	103 (30.9)
HPV-LR^1,2	27 (8.1)	3 (0.9)	26 (7.8)		2 (0.6)	1 (0.3)	3 (0.9)	0 (0.0)
6	3 (0.9)	1 (0.3)	4 (1.2)	0 (0.0)			0 (0.0)
11	2 (0.6)		2 (0.6)	0 (0.0)			0 (0.0)
HPV-HR^1,2	66 (19.8)	7 (2.1)	73 (21.9)	108 (32.4)		2 (0.6)	2 (0.6)	103 (30.9)
16	22 (6.6)	2 (0.6)	24 (7.2)	47 (14.1)		1 (0.3)		49 (14.7)
18	8 (2.4)		8 (2.4)	46 (13.8)				45 (13.5)
31	19 (5.7)	2 (0.6)	21 (6.3)	41 (12.3)				39 (11.7)
33	2 (0.6)	1 (0.3)	3 (0.9)	40 (12.0)^4				36 (10.8)^4
HPV-6,11,16,18	35 (10.5)	2 (0.6)	37 (11.1)		0 (0.0)	1 (0.3)	1 (0.3)

¹Percentages based on number of cases; ²HPV-HR= high risk types detected (HPV-16, 18, 31, 33, 39, 51, 56, 58, 59, 66, 70); HPV-LR= low risk types detected (HPV-6, 11, 53, 54, 61, 69, 83, 84, other/unnamed types); the number of HR and LR types do not sum to total number of HPV+ in cervical group because results represent the 2 cervical samples combined; and individuals may have multiple types, including both HR and LR types; ³number of HR types do not sum to total number of HPV+ because of multiple infections; ⁴data not available, some VLP types not tested.