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Infectious Diseases in Obstetrics and Gynecology
Volume 2010, Article ID 737425, 10 pages
http://dx.doi.org/10.1155/2010/737425
Review Article

Recent Advances in Understanding the Microbiology of the Female Reproductive Tract and the Causes of Premature Birth

1Initiative for Bioinformatics and Evolutionary Studies (IBEST), University of Idaho, Moscow, ID 83844-3051, USA
2Department of Biological Sciences, Life Sciences South, Rm. 441A, University of Idaho, Moscow, ID 83844-3150, USA
3Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201-1559, USA
4Department of Mathematics, University of Idaho, Moscow, ID 83844-3051, USA
5Department of Statistics, University of Idaho, Moscow, ID 83844-3051, USA

Received 16 April 2010; Accepted 25 October 2010

Academic Editor: Joseph Hwang

Copyright © 2010 Xia Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [52 citations]

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  • M. J. Czikk, F. P. McCarthy, and K. E. Murphy, “Chorioamnionitis: from pathogenesis to treatment,” Clinical Microbiology and Infection, pp. no–no, 2011. View at Publisher · View at Google Scholar
  • Gilberto E. Flores, Scott T. Bates, Dan Knights, Christian L. Lauber, Jesse Stombaugh, Rob Knight, and Noah Fierer, “Microbial Biogeography of Public Restroom Surfaces,” Plos One, vol. 6, no. 11, 2011. View at Publisher · View at Google Scholar
  • Katie L. Mason, and David M. Aronoff, “Postpartum Group A Streptococcus Sepsis and Maternal Immunology,” American Journal of Reproductive Immunology, vol. 67, no. 2, pp. 91–100, 2011. View at Publisher · View at Google Scholar
  • Benjamin C. Smith, Thomas McAndrew, Zigui Chen, Ariana Harari, David M. Barris, Shankar Viswanathan, Ana Cecilia Rodriguez, Phillip Castle, Rolando Herrero, Mark Schiffman, and Robert D. Burk, “The Cervical Microbiome over 7 Years and a Comparison of Methodologies for Its Characterization,” Plos One, vol. 7, no. 7, 2012. View at Publisher · View at Google Scholar
  • Susan M. Huse, Yuzhen Ye, Yanjiao Zhou, and Anthony A. Fodor, “A Core Human Microbiome as Viewed through 16S rRNA Sequence Clusters,” Plos One, vol. 7, no. 6, 2012. View at Publisher · View at Google Scholar
  • Kjersti Aagaard, Kevin Riehle, Jun Ma, Nicola Segata, Toni-Ann Mistretta, Cristian Coarfa, Sabeen Raza, Sean Rosenbaum, Ignatia Van den Veyver, Aleksandar Milosavljevic, Dirk Gevers, Curtis Huttenhower, Joseph Petrosino, and James Versalovic, “A Metagenomic Approach to Characterization of the Vaginal Microbiome Signature in Pregnancy,” Plos One, vol. 7, no. 6, 2012. View at Publisher · View at Google Scholar
  • M. A. Underwood, A. E. Wartell, and R. A. Borghese, “Hyperleukocytosis in a premature infant with intrauterine herpes simplex encephalitis,” Journal Of Perinatology, vol. 32, no. 6, pp. 469–472, 2012. View at Publisher · View at Google Scholar
  • B. W. Brandt, M. J. Bonder, S. M. Huse, and E. Zaura, “TaxMan: a server to trim rRNA reference databases and inspect taxonomic coverage,” Nucleic Acids Research, vol. 40, no. W1, pp. W82–W87, 2012. View at Publisher · View at Google Scholar
  • David Mabey, Carine Ronsmans, R. Matthew Chico, Daniel Chandramohan, Cono Ariti, and Philippe Mayaud, “Prevalence of Malaria and Sexually Transmitted and Reproductive Tract Infections in Pregnancy in Sub-Saharan Africa A Systematic Review,” Jama-Journal Of The American Medical Association, vol. 307, no. 19, pp. 2079–2086, 2012. View at Publisher · View at Google Scholar
  • Jennifer M. Fettweis, Myrna G. Serrano, Philippe H. Girerd, Kimberly K. Jefferson, and Gregory A. Buck, “A New Era of the Vaginal Microbiome: Advances Using Next-Generation Sequencing,” Chemistry & Biodiversity, vol. 9, no. 5, pp. 965–976, 2012. View at Publisher · View at Google Scholar
  • Ido Solt, and Offer Cohavy, “The great obstetrical syndromes and the human microbiome-a new frontier.,” Rambam Maimonides medical journal, vol. 3, no. 2, 2012. View at Publisher · View at Google Scholar
  • Ryan Rampersaud, Tara M. Randis, and Adam J. Ratner, “Microbiota of the upper and lower genital tract,” Seminars in Fetal & Neonatal Medicine, vol. 17, no. 1, pp. 51–57, 2012. View at Publisher · View at Google Scholar
  • Jean M. MacKlaim, Gregor Reid, Craig R. Cohen, Gilbert Donders, Gregory B. Gloor, Janet E. Hill, Groesbeck P. Parham, Jacques Ravel, Gregory Spear, and Janneke Van De Wijgert, “Exploring a road map to counter misconceptions about the cervicovaginal microbiome and disease,” Reproductive Sciences, vol. 19, no. 11, pp. 1154–1162, 2012. View at Publisher · View at Google Scholar
  • Wilhelmina M Huston, Marina Harvie, Aruna Mittal, Peter Timms, and Kenneth W Beagley, “Vaccination to protect against infection of the female reproductive tract,” Expert Review of Clinical Immunology, vol. 8, no. 1, pp. 81–94, 2012. View at Publisher · View at Google Scholar
  • Laura K. Sycuro, and David N. Fredricks, “Microbiota of the Genitourinary Tract,” The Human Microbiota, pp. 167–210, 2013. View at Publisher · View at Google Scholar
  • Karen Racicot, Ingrid Cardenas, Vera Wuensche, Paulomi Aldo, Seth Guller, Robert E. Means, Roberto Romero, and Gil Mor, “Viral Infection of the Pregnant Cervix Predisposes to Ascending Bacterial Infection,” Journal of Immunology, vol. 191, no. 2, pp. 934–941, 2013. View at Publisher · View at Google Scholar
  • Linnet Masese, R. Scott McClelland, Ruth Gitau, George Wanje, Juma Shafi, Francis Kashonga, Jeckoniah O. Ndinya-Achola, Richard Lester, Barbra A. Richardson, and Ann Kurth, “A pilot study of the feasibility of a vaginal washing cessation intervention among Kenyan female sex workers,” Sexually Transmitted Infections, vol. 89, no. 3, pp. 217–222, 2013. View at Publisher · View at Google Scholar
  • W. Parker, and J. Ollerton, “Evolutionary biology and anthropology suggest biome reconstitution as a necessary approach toward dealing with immune disorders,” Evolution, Medicine, and Public Health, vol. 2013, no. 1, pp. 89–103, 2013. View at Publisher · View at Google Scholar
  • Roberto Romero, and Steven J. Korzeniewski, “Are infants born by elective cesarean delivery without labor at risk for developing immune disorders later in life?,” American Journal of Obstetrics and Gynecology, vol. 208, no. 4, pp. 243–246, 2013. View at Publisher · View at Google Scholar
  • Camila Marconi, Gilbert G. Donders, Cristina M. G. L. Parada, Paulo C. Giraldo, and Marcia Guimaraes da Silva, “Do Atopobium vaginae, Megasphaera sp and Leptotrichia sp change the local innate immune response and sialidase activity in bacterial vaginosis?,” Sexually Transmitted Infections, vol. 89, no. 2, pp. 167–173, 2013. View at Publisher · View at Google Scholar
  • Eve M Lackritz, Christopher B Wilson, Alan E Guttmacher, Jennifer L Howse, Cyril M Engmann, Craig E Rubens, Elizabeth M Mason, Louis J Muglia, Michael G Gravett, Robert L Goldenberg, Jeffrey C Murray, Catherine Y Spong, and Joe Leigh Simpson, “A solution pathway for preterm birth: accelerating a priority research agenda,” The Lancet Global Health, 2013. View at Publisher · View at Google Scholar
  • Gregor Reidpp. 45–56, 2013. View at Publisher · View at Google Scholar
  • Rebecca M. Stumpf, Brenda A. Wilson, Angel Rivera, Suleyman Yildirim, Carl J. Yeoman, John D. Polk, Bryan A. White, and Steven R. Leigh, “The primate vaginal microbiome: Comparative context and implications for human health and disease,” American Journal of Physical Anthropology, 2013. View at Publisher · View at Google Scholar
  • George L. Mendz, Nadeem O. Kaakoush, and Julie A. Quinlivan, “Bacterial aetiological agents of intra-amniotic infections and preterm birth in pregnant women,” Frontiers in Cellular and Infection Microbiology, vol. 3, 2013. View at Publisher · View at Google Scholar
  • Jing Cheng, Airi M. Palva, Willem M. de Vos, Reetta Satokari, Jing Cheng, Airi M. Palva, Willem M. de Vos, and Reetta Satokari, “Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age,” Between Pathogenicity and Commensalism, vol. 358, pp. 323–346, 2013. View at Publisher · View at Google Scholar
  • Jorge L. Cervantes, and Bo-Young Hong, “Role of Next-Generation Sequencing in Understanding the Interactions between Human Papillomavirus and the Cervicovaginal Microbiome,” Gynecologic and Obstetric Investigation, vol. 76, no. 4, pp. 195–202, 2013. View at Publisher · View at Google Scholar
  • Radhikas. Ganu, Jun Ma, and Kjersti M. Aagaard, “The role of microbial communities in parturition: Is there evidence of association with preterm birth and perinatal morbidity and mortality?,” American Journal of Perinatology, vol. 30, no. 8, pp. 613–624, 2013. View at Publisher · View at Google Scholar
  • Ido Solt, “The human microbiome and the great obstetrical syndromes, a new frontier in maternal fetal medicine,” Best Practice & Research Clinical Obstetrics & Gynaecology, 2014. View at Publisher · View at Google Scholar
  • Suleyman Yildirim, Carl J Yeoman, Sarath Chandra Janga, Susan M Thomas, Mengfei Ho, Steven R Leigh, Primate Microbiome Consortium, Bryan A White, Brenda A Wilson, and Rebecca M Stumpf, “Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance,” The ISME Journal, 2014. View at Publisher · View at Google Scholar
  • Ashok Aiyar, Alison J. Quayle, Lyndsey R. Buckner, Shardulendra P. Sherchand, Theresa L. Chang, Arnold H. Zea, David H. Martin, and Robert J. Belland, “Influence of the tryptophan-indole-IFN gamma axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections,” Frontiers in Cellular and Infection Microbiology, vol. 4, 2014. View at Publisher · View at Google Scholar
  • Helena Mendes-Soares, Haruo Suzuki, Roxana J. Hickey, and Larry J. Forney, “Comparative Functional Genomics of Lactobacillus spp. Reveals Possible Mechanisms for Specialization of Vaginal Lactobacilli to Their Environment,” Journal of Bacteriology, vol. 196, no. 7, pp. 1458–1470, 2014. View at Publisher · View at Google Scholar
  • Janet C. Jacobson, David K. Turok, Amna I. Dermish, Ingrid E. Nygaard, and Matthew L. Settles, “Vaginal microbiome changes with levonorgestrel intrauterine system placement,” Contraception, 2014. View at Publisher · View at Google Scholar
  • Manju Chandiramani, Phillip R. Bennett, Richard Brown, Yun S. Lee, and David A. Macintyre, “Vaginal microbiome-pregnant host interactions determine a significant proportion of preterm labour,” Fetal and Maternal Medicine Review, vol. 25, no. 1, pp. 73–78, 2014. View at Publisher · View at Google Scholar
  • JoonHo Lee, Roberto Romero, Sun Min Kim, Piya Chaemsaithong, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, and Bo Hyun Yoon, “A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM,” The Journal of Maternal-Fetal & Neonatal Medicine, pp. 1–14, 2015. View at Publisher · View at Google Scholar
  • Guillermo Álvarez-Calatayud, Juan Miguel Rodríguez, Evaristo Suárez, and Jimena Pérez-Moreno, “Microbiota in women; Clinical applications of probiotics,” Nutricion Hospitalaria, vol. 32, pp. 56–61, 2015. View at Publisher · View at Google Scholar
  • Dane B. Nenadic, Milos D. Pavlovic, and Tatjana Motrenko, “A novel microscopic method for analyzing Gram-stained vaginal smears in the diagnosis of disorders of vaginal microflora,” Vojnosanitetski Pregled, vol. 72, no. 8, pp. 670–676, 2015. View at Publisher · View at Google Scholar
  • Helena Mendes-Soares, Vandhana Krishnan, Matthew L. Settles, Jacques Ravel, Celeste J. Brown, and Larry J. Forney, “Fine-scale analysis of 16S rRNA sequences reveals a high level of taxonomic diversity among vaginal Atopobium spp.,” Pathogens And Disease, vol. 73, no. 4, 2015. View at Publisher · View at Google Scholar
  • Marian Kacerovsky, Filip Vrbacky, Radka Kutova, Lenka Pliskova, Ctirad Andrys, Ivana Musilova, Ramkumar Menon, Ronald Lamont, and Jana Nekvindova, “Cervical microbiota in women with preterm prelabor rupture of membranes,” PLoS ONE, vol. 10, no. 5, 2015. View at Publisher · View at Google Scholar
  • Belén Padilla-Ortega, Susana Delgado-Palacio, Fernando García-Garrote, Juan Miguel Rodríguez-Gómez, and Beatriz Romero-Hernández, “Diagnóstico microbiológico de la infección bacteriana asociada al parto y puerperio,” Enfermedades Infecciosas y Microbiología Clínica, 2015. View at Publisher · View at Google Scholar
  • Chelsea Fox, and Kacey Eichelberger, “Maternal microbiome and pregnancy outcomes,” Fertility and Sterility, 2015. View at Publisher · View at Google Scholar
  • Debra Tristram, “Maternal Genital Tract Infection,” Mucosal Immunology, pp. 2215–2229, 2015. View at Publisher · View at Google Scholar
  • Deborah B. Nelson, L. Christie Rockwell, Morgan D. Prioleau, and Laura Goetzl, “The role of the bacterial microbiota on reproductive and pregnancy health,” Anaerobe, 2016. View at Publisher · View at Google Scholar
  • Jael A. Obiero, Kenneth K. Waititu, Isaac Mulei, Farah I. Omar, Walter Jaoko, and Peter G. Mwethera, “Baboon vaginal microbial flora,” Journal of Medical Primatology, 2016. View at Publisher · View at Google Scholar
  • Jian Shen, Ning Song, Christopher J. Williams, Celeste J. Brown, Zheng Yan, Chen Xu, and Larry J. Forney, “Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis,” Scientific Reports, vol. 6, pp. 24380, 2016. View at Publisher · View at Google Scholar
  • Jae Young Yoo, Mina Rho, Young-Ah You, Eun Jin Kwon, Min-Hye Kim, Sungmin Kym, Young-Koo Jee, Yoon-Keun Kim, and Young Ju Kim, “16S rRNA gene-based metagenomic analysis reveals differences in bacteria-derived extracellular vesicles in the urine of pregnant and non-pregnant women,” Experimental & Molecular Medicine, vol. 48, no. 2, pp. e208, 2016. View at Publisher · View at Google Scholar
  • María Encarnación Morales, and María Adolfina Ruiz, “Microencapsulation of probiotic cells: applications in nutraceutic and food industry,” Nutraceuticals, pp. 627–668, 2016. View at Publisher · View at Google Scholar
  • Aline C. Freitas, Bonnie Chaban, Alan Bocking, Maria Rocco, Siwen Yang, Janet E. Hill, and Deborah M. Money, “The vaginal microbiome of pregnant women is less rich and diverse, with lower prevalence of Mollicutes, compared to non-pregnant women,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Diogo Antonio Tschoeke, Louisi Souza de Oliveira, Luciana Leomil, Amilcar Tanuri, and Fabiano Lopes Thompson, “Pregnant women carrying microcephaly foetuses and Zika virus contain potentially pathogenic microbes and parasites in their amniotic fluid,” BMC Medical Genomics, vol. 10, no. 1, 2017. View at Publisher · View at Google Scholar
  • Mai He, Alison R. Migliori, Patricia Lauro, C. James Sung, and Halit Pinar, “Perinatal Mortality Associated with Positive Postmortem Cultures for Common Oral Flora,” Infectious Diseases in Obstetrics and Gynecology, vol. 2017, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Roberto Romero, Piya Chaemsaithong, Lami Yeo, Nikolina Docheva, and Noppadol Chaiyasit, “Fetal and Maternal Responses to Intraamniotic Infection,” Fetal and Neonatal Physiology, pp. 144–159.e12, 2017. View at Publisher · View at Google Scholar
  • Pamela Pruski, Holly V. Lewis, Yun S. Lee, Julian R. Marchesi, Phillip R. Bennett, Zoltan Takats, and David A. MacIntyre, “Assessment of microbiota:host interactions at the vaginal mucosa interface,” Methods, 2018. View at Publisher · View at Google Scholar
  • Noelle Noyes, Kyu-Chul Cho, Jacques Ravel, Larry J. Forney, and Zaid Abdo, “Associations between sexual habits, menstrual hygiene practices, demographics and the vaginal microbiome as revealed by Bayesian network analysis,” Plos One, vol. 13, no. 1, pp. e0191625, 2018. View at Publisher · View at Google Scholar