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Infectious Diseases in Obstetrics and Gynecology
Volume 2011 (2011), Article ID 319460, 8 pages
http://dx.doi.org/10.1155/2011/319460
Research Article

Bacterial Vaginosis and the Natural History of Human Papillomavirus

1Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, NCCDPHP, DRH, 4770 Buford Highway, Mailstop K-34, Atlanta, GA 30341, USA
2Department of Obstetrics and Gynecology, Alpert Medical School of Brown University, Providence, RI 02912, USA
3Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
4Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
5Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
6Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201-1998, USA

Received 6 May 2011; Accepted 7 June 2011

Academic Editor: Gregory T. Spear

Copyright © 2011 Caroline C. King et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate associations between common vaginal infections and human papillomavirus (HPV). Study Design. Data from up to 15 visits on 756 HIV-infected women and 380 high-risk HIV-uninfected women enrolled in the HIV Epidemiology Research Study (HERS) were evaluated for associations of bacterial vaginosis, trichomoniasis, and vaginal Candida colonization with prevalent HPV, incident HPV, and clearance of HPV in multivariate analysis. Results. Bacterial vaginosis (BV) was associated with increased odds for prevalent (aOR = 1.14, 95% CI: 1.04, 1.26) and incident (aOR = 1.24, 95% CI: 1.04, 1.47) HPV and with delayed clearance of infection (aHR = 0.84, 95% CI: 0.72, 0.97). Whereas BV at the preceding or current visit was associated with incident HPV, in an alternate model for the outcome of incident BV, HPV at the current, but not preceding, visit was associated with incident BV. Conclusion. These findings underscore the importance of prevention and successful treatment of bacterial vaginosis.