Safety and Tolerability of Antiretrovirals during Pregnancy

Table 3

Drug substitutions or discontinuations during pregnancy.

Class	Drug	𝑁 events/𝑁 pregnancies	Percent (95% confidence interval)
NRTI		11/114#	10 (5–17)
	AZT	10/99	10 (5–18)
	3TC	0/109	0 (0–3)
	d4T	0/23	0 (0–15)
	ABC	1/8	13 (0–53)
	ddI	0/6	0 (0–46)
	TDF	0/2	0 (0–84)
	FTC	0/1	0 (0–98)
NNRTI		3/20#∗	15 (3–38)
	NVP	3/19	16 (1–33)
	DLV	0/1	0 (0–98)
	EFV	2/2	n.a.
PI		8/97#	8 (4–16)
	NFV	6/64	9 (4–19)
	LPV/RTV	2/28	1 (1–24)
	IDV	0/5	0 (0–60)
	IDV/RTV	0/1	0 (0–98)
	SQV	0/2	0 (0–84)
	SQV/RTV	2/9	22 (3–60)

∗Excludes EFV substitutions.
#In the drug class summary, a pregnancy in which ≥2 drugs from the same class were substituted was counted only once.