Table of Contents Author Guidelines Submit a Manuscript
Infectious Diseases in Obstetrics and Gynecology
Volume 2011, Article ID 989762, 8 pages
Research Article

The Role of Chlamydia trachomatis Polymorphic Membrane Proteins in Inflammation and Sequelae among Women with Pelvic Inflammatory Disease

1Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
2Department of Epidemiology, Michigan State University, 644 West Fee Hall, East Lansing, MI 48824, USA
3Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
4Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, MD 21201, USA
5School of Public Health, The University of Texas Health Science Center, Houston, TX 77030, USA

Received 2 June 2011; Revised 30 July 2011; Accepted 10 August 2011

Academic Editor: Thomas Cherpes

Copyright © 2011 Brandie D. Taylor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chlamydia trachomatis polymorphic membrane proteins (Pmps) may increase genital tract inflammation and play a role in virulence. Antibody levels for PmpA, PmpD, and PmpI, measured in densitometric units, were assessed among a pilot sample of 40 C. trachomatis-infected women with mild-to-moderate clinical PID. Women who expressed antibodies to PmpA were less likely to achieve pregnancy (40.0% versus 85.7%; 𝑃 = 0 . 0 4 2 ) and less likely to have a live birth (0.0% versus 80.0%; 𝑃 = 0 . 0 0 5 ) compared to women who did not express antibody to PmpA. Women who expressed antibodies to PmpI were more likely to have upper genital tract infection (61.5% versus 20.0%; 𝑃 = 0 . 0 2 6 ). However, seropositivity to PmpI and PmpD did not modify the risk of reproductive sequelae or inflammation. Seropositivity to chlamydial PmpA may represent a biomarker of increased risk of sequelae secondary to infection with C. trachomatis.