Clinical Study

Effect of HSV-2 Suppressive Therapy on Genital Tract HIV-1 RNA Shedding among Women on HAART: A Pilot Randomized Controlled Trial

Table 2

Cumulative frequencies of clinical characteristics (visits 1–12).

Acyclovir ( visits)No acyclovir ( visits)Overall ( visits)

Trichomonas1 (0.3%)6 (2%)7 (1%)
Candida29 (9%)29 (10%)58 (10%)
Bacterial vaginosis104 (33%)76 (26%)180 (30%)
Semen detected19 (6%)11 (4%)30 (5%)
>100 GT leukocytes133 (42%)153 (52%)286 (47%)
Detectable asymptomatic HSV10 (3%)30 (10%)40 (6%)
Detectable PVL56 (18%)26 (9%)83 (14%)
Detectable GT HIV40 (12%)28 (9%)68 (11%)
Missed ≥ 1 ARV dose in 2 wk61 (19%)61 (20%)122 (20%)
Missed ≥1 Acyclovir dose in 2 wk88 (31%)N/AN/A

NOTE. GT, Genital Tract; HSV, herpes simplex virus; PVL, plasma viral load; ARV, antiretroviral.