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Infectious Diseases in Obstetrics and Gynecology
Volume 2013, Article ID 140142, 6 pages
http://dx.doi.org/10.1155/2013/140142
Research Article

Avidity of Antibodies against HSV-2 and Risk to Neonatal Transmission among Mexican Pregnant Women

1Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad No. 655, Colonia Santa María Ahuacatitlán, Cerrada Los Pinos y Caminera, CP 62100, Cuernavaca, Morelos, Mexico
2Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Avenida Universidad No. 655, Colonia Santa María Ahuacatitlán, Cerrada Los Pinos y Caminera, CP 62100, Cuernavaca, Morelos, Mexico
3Universidad Politécnica del Estado de Morelos, Boulevard Cuauhnáhuac No. 566, Colonia Lomas del Texcal, CP 62550, Jiutepec, Morelos, Mexico

Received 30 April 2013; Accepted 2 July 2013

Academic Editor: Lu-Yu Hwang

Copyright © 2013 Antonia Herrera-Ortiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To determine HSV-2 seroprevalence, risk factors, and antibody avidity among a sample of Mexican pregnant women. Material and Methods. The avidity test was standardized with different urea concentrations and incubation times; the cut-off point was calculated to determine the low avidity (early infection). IgG antibodies against HSV-2 were detected from pregnant and postpartum women from Morelos, Mexico, and the avidity test was performed to positive samples. Multivariate regression logistic analysis was employed to evaluate demographic and sexual behavior characteristics associated with HSV-2 infection. Results. HSV-2 seroprevalence among Mexican women analyzed was 14.5% (333/2300), demographic factors (location of General Hospital, age, education level, and civil status), and risky sexual behaviors (STI self-report and number of sexual partners during last year) were associated with HSV-2 infection. Seventeen women were detected with low avidity antibodies (early infection) with a cut-off point of 66.1%. Conclusions. HSV-2 infection was common among this group of women from Mexico; the avidity test detected women with recent infections, and these women were more likely to transmit HSV-2 to their neonates. Neonatal herpes has no epidemiological surveillance, the disease could be overlooked, and so more studies are needed to estimate the magnitude of neonatal infection.