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Infectious Diseases in Obstetrics and Gynecology
Volume 2013 (2013), Article ID 525878, 6 pages
Clinical Study

Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis

1Department of Obstetrics & Gynecology, Kelsey-Seybold West Clinic, 1111 Augusta Drive, Houston, TX 77057, USA
2Kelsey Research Foundation, 5615 Kirby Drive, Suite 660, Houston, TX 77005, USA
3Department of Pediatrics, Kelsey-Seybold Clinic, Kelsey-Seybold Main Campus, 2727 West Holcombe Boulevard, Houston, TX 77025, USA

Received 27 November 2012; Accepted 8 March 2013

Academic Editor: Bryan Larsen

Copyright © 2013 Mark A. Turrentine et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Infants born to mothers who are colonized with group B streptococcus (GBS) but received <4 hours of intrapartum antibiotic prophylaxis (IAP) are at-risk for presenting later with sepsis. We assessed if <4 hours of maternal IAP for GBS are associated with an increased incidence of clinical neonatal sepsis. Materials and Methods. A retrospective cohort study of women-infant dyads undergoing IAP for GBS at ≥37-week gestation who presented in labor from January 1, 2003 through December 31, 2007 was performed. Infants diagnosed with clinical sepsis by the duration of maternal IAP received (< or ≥4-hours duration) were determined. Results. More infants whose mothers received <4 hours of IAP were diagnosed with clinical sepsis, 13 of 1,149 (1.1%) versus 15 of 3,633 (0.4%), . Multivariate logistic regression analysis showed that treatment with ≥4 hours of IAP reduced the risk of infants being diagnosed with clinical sepsis by 65%, adjusted relative risk 0.35, CI 0.16–0.79, and . Conclusion. The rate of neonatal clinical sepsis is increased in newborns of GBS colonized mothers who receive <4 hours compared to ≥4 hours of IAP.