Guideline Adherence for Intrapartum Group B Streptococci Prophylaxis in Penicillin-Allergic Patients
Table 3
GBS+, penicillin-allergic patients who delivered at Magee-Womens Hospital in 2010. Comparisons between women who received appropriate antibiotic* and women who did not.
Characteristics
Received appropriate antibiotic
Did not receive appropriate antibiotic
P
Number
Percent (95% CI)
Number
Percent (95% CI)
Total (n = 135)
84
51
Race/ethnicity
0.47
Non-Hispanic White
72
85.7 (76.5–91.8)
41
80.4 (67.4–89.2)
Non-Hispanic African-American
12
14.3 (8.2–23.5)
9
17.6 (9.3–30.5)
Other
0
0.0 (0–5.2)
1
2 (0–11.3)
Type of insurance
0.05
Private
65
77.4 (67.3–85.1)
31
60.8 (47.1–73.0)
Medical assistance
19
22.6 (14.9–32.7)
20
39.2 (27.0–52.9)
Obstetric provider type
0.7
Private physician
61
72.6 (62.2–81.1)
37
72.5 (59.0–83.0)
Maternal fetal medicine
2
2.4 (0.2–8.8)
1
2 (0–11.3)
OB/GYN residents
14
16.7 (10.1–26.2)
11
21.6 (12.3–34.8)
Midwife
6
7.1 (3.0–15.0)
1
2 (0–11.3)
Family practitioner
1
1.2 (0–7.1)
1
2 (0–11.3)
Type of antibiotics received
0.006
Cephalosporin
27
32.1 (23.1–42.8)
14
27.5 (17.0–41.0)
Clindamycin
28
33.3 (24.2–44)
26
51 (37.7–64.1)
Erythromycin
0
0.0 (0–5.2)
2
3.9 (0.3–14.0)
Vancomycin
29
34.5 (25.2–45.2)
7
13.7 (6.5–26.0)
Penicillin
0
0.0 (0–5.2)
2
3.9 (0.3–14.0)
Appropriate antibiotic is defined according to 2002 CDC guidelines. (i) Cephalosporin for patients at low risk of anaphylaxis (those who had no immediate hypersensitivity reaction to penicillin or had previously tolerated a cephalosporin). (ii) Clindamycin or erythromycin for patients whose GBS isolates were susceptible to both of these antibiotics. (iii) Vancomycin for patients at high or unknown risk of anaphylaxis when antimicrobial sensitivity was unknown or the GBS isolates were resistant to either clindamycin or erythromycin.
