Research Article

Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species

Table 1

MIC values for time-kill assay Candida strains in VSM (pH 4.2) or RPMI (pH 7.0).

SpeciesStrainFLU (S/R)2MIC (μg/ml)1
RZFTERFLUAMB
VSMRPMIVSMRPMIVSMRPMIVSMRPMI

C. albicansATCC 44858S0.060.032321110.125
DPL001R0.030.066432128>1280.50.125
R357R0.50.254320.5>1280.50.25

C. glabrataCG01S0.030.0680.01516110.5
ATCC 200918R30.1250.06>1281>1283210.5
MMX 7070R0.250.03>1282>128640.50.25

C. tropicalisCT02S0.060.064420.510.25
MMX 7255R0.1250.03>12864>128640.50.5
MMX 7525R0.1250.06>1284>1281280.50.5

C. parapsilosisCP02S2240.0320.2510.25
CP01R22320.125>1281610.25
MMX 7370R21320.5646410.5

C. kruseiATCC 6258R0.1250.06160.5643210.5
ATCC 14243R0.060.06320.5643210.5

values were determined three times, independently. At most there was a 2-fold range in variation for each drug/strain combination MIC value between replicates and modal values are listed. 2Susceptibility to FLU as defined per CLSI 24 h broth microdilution interpretive criteria [21]. 3ATCC describes strain 200918 as FLU-R strain although the CLSI MIC value of 32 μg/ml derived in this study is technically characterized as “susceptible-dose dependent” per CLSI interpretive criteria [21].