Infectious Diseases in Obstetrics and Gynecology / 2020 / Article / Tab 4

Research Article

Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens

Table 4

Crude and adjusted risk ratios for pregnancy outcomes for azithromycin versus erythromycin regimens for nulliparous patients.

CrudeAdjusted
RR95% CIRR95% CI

Clinical chorioamnionitis0.430.23 to 0.810.0060.390.20 to 0.750.003
Histologic chorioamnionitis0.960.70 to 1.300.7840.940.69 to 1.300.724
Postpartum endometritis0.500.28 to 0.870.0120.470.26 to 0.850.010
Composite intra-amniotic infection/inflammation0.810.62 to 1.060.1270.780.59 to 1.040.092
Composite clinical infectious morbidity0.470.31 to 0.71<0.0010.430.28 to 0.67<0.001
Neonatal sepsis (positive blood culture)0.190.07 to 0.57<0.0010.200.07 to 0.59<0.001
Cesarean delivery1.190.81 to 1.760.3761.240.83 to 1.850.299
Meconium-stained amniotic fluid1.480.84 to 2.610.1761.400.78 to 2.520.263

Models were adjusted for maternal age, advanced maternal age, gestational age at diagnosis of PPROM, nulliparity, BMI, pregestational diabetes, group ß-streptococcus positive (bacteriuria), any hypertensive disorder in pregnancy, and race. values calculated using the likelihood ratio test. Estimates are calculated via modified Poisson generalized linear models. RR = risk ratio; CI = confidence interval.

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