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International Journal of Analytical Chemistry
Volume 2009, Article ID 153472, 13 pages
http://dx.doi.org/10.1155/2009/153472
Research Article

LC/MS/MS Analysis of N-Terminal Protein Adducts with Improved Sensitivity: A Comparison of Selected Edman Isothiocyanate Reagents

1Arrhenius Laboratory, Department of Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden
2Department of Applied Environmental Science, Stockholm University, 106 91 Stockholm, Sweden
3PerkinElmer Sverige AB, Oxfordhuset, Johanneslundsvägen 2, 194 81 Upplands Väsby, Sweden

Received 22 April 2009; Accepted 1 August 2009

Academic Editor: Shoji Motomizu

Copyright © 2009 Per Rydberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [9 citations]

The following is the list of published articles that have cited the current article.

  • Hans von Stedingk, Per Rydberg, and Margareta Tornqvist, “A new modified Edman procedure for analysis of N-terminal valine adducts in hemoglobin by LC-MS/MS,” Journal Of Chromatography B-Analytical Technologies In The Biomedical And L, vol. 878, no. 27, pp. 2483–2490, 2010. View at Publisher · View at Google Scholar
  • Hans von Stedingk, Ronnie Davies, Per Rydberg, and Margareta Tornqvist, “Methyl vinyl ketone-Identification and quantification of adducts to N-terminal valine in human hemoglobin,” Journal Of Chromatography B-Analytical Technologies In The Biomedical And L, vol. 878, no. 27, pp. 2491–2496, 2010. View at Publisher · View at Google Scholar
  • Hans von Stedingk, Anna C. Vikstrom, Per Rydberg, Marie Pedersen, Jeanette K. S. Nielsen, Dan Segerback, Lisbeth E. Knudsen, and Margareta Tornqvist, “Analysis of Hemoglobin Adducts from Acrylamide, Glycidamide, and Ethylene Oxide in Paired Mother/Cord Blood Samples from Denmark,” Chemical Research In Toxicology, vol. 24, no. 11, pp. 1957–1965, 2011. View at Publisher · View at Google Scholar
  • Hans von Stedingk, Hanjing Xie, Thomas Hatschek, Theodoros Foukakis, Andreas Rydén, Jonas Bergh, and Per Rydberg, “Validation of a novel procedure for quantification of the formation of phosphoramide mustard by individuals treated with cyclophosphamide,” Cancer Chemotherapy and Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Henrik Carlsson, Hans von Stedingk, Ulrika Nilsson, and Margareta Törnqvist, “LC–MS/MS Screening Strategy for Unknown Adducts to N-Terminal Valine in Hemoglobin Applied to Smokers and Nonsmokers,” Chemical Research in Toxicology, pp. 141106154227008, 2014. View at Publisher · View at Google Scholar
  • Henrik Carlsson, Hitesh V. Motwani, Siv Osterman Golkar, and Margareta Törnqvist, “Characterization of a Hemoglobin Adduct from Ethyl Vinyl Ketone Detected in Human Blood Samples,” Chemical Research in Toxicology, pp. 151021110634004, 2015. View at Publisher · View at Google Scholar
  • Friederike Manig, Konstantin Kuhne, Cläre von Neubeck, Uwe Schwarzenbolz, Zhanru Yu, Benedikt M. Kessler, Jens Pietzsch, and Leoni A. Kunz-Schughart, “The Why and How of Amino Acid Analytics in Cancer Diagnostics and Therapy,” Journal of Biotechnology, 2016. View at Publisher · View at Google Scholar
  • Henrik Carlsson, Jenny Aasa, Natalia Kotova, Daniel Vare, Pedro F. M. Sousa, Per Rydberg, Lilianne Abramsson-Zetterberg, and Margareta Törnqvist, “Adductomic Screening of Hemoglobin Adducts and Monitoring of Micronuclei in School-Age Children,” Chemical Research in Toxicology, 2017. View at Publisher · View at Google Scholar
  • Henrik Carlsson, Stephen Rappaport, and Margareta Törnqvist, “Protein Adductomics: Methodologies for Untargeted Screening of Adducts to Serum Albumin and Hemoglobin in Human Blood Samples,” High-Throughput, vol. 8, no. 1, pp. 6, 2019. View at Publisher · View at Google Scholar