A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance

<table>Potential fragments produced
by acid hydrolysis of Unknown 2. Structures on the left represent fragments
expected to be generated from the thioether, those on the right from the bis-sulfoxide.  Fragment 241 would be common to both
structures.</table>

International Journal of Analytical Chemistry

fig6

Figure 6

Figure 6: A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance 