A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance

<table>Proposed structures and
formation pathway for the two unknown impurities in AMG 517.</table>

International Journal of Analytical Chemistry

Figure 9: A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance 