International Journal of Analytical Chemistry / 2009 / Article / Tab 2

Research Article

A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance

Table 2

and chemical shifts (δ/ppm) of AMG 517 standard in DMSO-d6 (400 MHz).

768743.tab.002

Position ( /ppm, J/Hz) (a) ( /ppm) (a)

1130.9 (q, = 31.9 Hz)
2, 67.92 (d, 2H, J = 8.2 Hz) (b) 125.9 (q, = 3.7 Hz)
3, 58.44 (d, 2H, J = 8.2 Hz)128.0
4139.7
7163.4
98.79 (s, 1H)158.6 (e)
11170.3 (d)
127.97 (s, 1H)104.2
13124.0 (q, = 272.2 Hz)
15143.5
167.35 (m, 1H) (c) 119.1
177.39 (t, 1H, J = 7.7 Hz) (c) 124.2
187.93 (m, 1H) (b) 119.6
19133.6
20141.4
22158.4 (e)
2412.42 (s, 1H)
25169.5 (d)
262.13 (s, 3H)22.6

(a) Signal splitting patterns: s = singlet, d = doublet, t = triplet, q = quartet, m = multiplet; (b), (c) overlapping; (d), (e) interchangeable assignment.

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