Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate

Table 2

Quantitative parameters and statistical data for determination of amantadine hydrochloride by the proposed spectrophotometric and spectrofluorometric methods.

Parameter	Spectrophotometric method	Spectrofluorometric method
Range (𝜇g mL^−1)	5.00–80.0	0.05–10.0
Intercept (a)	0.0759±0.0041	−2.457±0.332
Slope (b)	0.00974±0.00035	81.969±2.154
Correlation coefficient (r)	0.9974	0.9972
𝜀×10^3(Lmol^−1cm^−1)	2.058	—
LOD (𝜇g mL^−1)	1.39	0.013
LOQ (𝜇g mL^−1)	4.21	0.041