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International Journal of Analytical Chemistry
Volume 2009 (2009), Article ID 954083, 7 pages
Research Article

Preparation, Characterization, and Analytical Application of Ramipril Membrane-Based Ion-Selective Electrode

1Hot Laboratories Center, Atomic Energy Authority, Cairo 13759, Egypt
2Girls College, Ain Shams University, Cairo 11757, Egypt

Received 10 August 2008; Revised 12 January 2009; Accepted 14 January 2009

Academic Editor: Jan Åke Jönsson

Copyright © 2009 Hassan Arida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The fabrication and electrochemical evaluation of two PVC membrane-based Ion-Selective electrodes responsive for ramipril drug have been proposed. The sensitive membranes were prepared using ramipril-phosphomolibdate and ramipril-tetraphenylborate ion-pair complexes as electroactive sensing materials in plasticized PVC support. The electrodes based on these materials provide near-Nernestian response (sensitivity of  mV/concentration decade) covering the concentration range of  mol with a detection limit of  mol . The suggested electrodes have been successfully used in the determination of ramipril drug in some pharmaceutical formulations using direct potentiometry with average recovery of >96% and mean standard deviation of <3% ().