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International Journal of Analytical Chemistry
Volume 2010, Article ID 704564, 5 pages
Research Article

Sensitive Spectrophotometric Method for Quantitation of Guaifenesin and Dropropizine in Their Dosage Forms

Faculty of Pharmacy , October University for Modern Sciences and Arts, El Wahat Road, 6th October City, Egypt

Received 17 February 2010; Accepted 11 May 2010

Academic Editor: Maria Augusta Raggi

Copyright © 2010 Ola M. Abdallah. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Guaifenesin and dropropizine were analyzed through oxidation with periodic acid to give formaldehyde which was allowed to condense with 4-Amino-5-hydrazino-4H [1,2,4]-triazole-3-thiol (AHTT). The condensation product was further oxidized to yield a purple colored compound with maximum absorption at 550 nm. Beer's law was obeyed in the range of 5–45  𝜇 g m L − 1 for guaifenesin and 10–80  𝜇 g m L − 1 for dropropizine. Both drugs were also successfully determined in their dosage forms.