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International Journal of Analytical Chemistry
Volume 2011 (2011), Article ID 124917, 6 pages
Research Article

Stability Indicating HPLC Determination of Risperidone in Bulk Drug and Pharmaceutical Formulations

1Department of Pharmaceutical Analysis, Veerayatan Institute of Pharmacy, Gujarat, Kutch, India
2Department of Pharmaceutical Sciences, Saurashtra University, Gujarat, Rajkot, India
3K. B. Institute of pharmaceutical Education and Research, Gandhinagar, India
4CVM Institute for Degree Course in Pharmacy, New Vallabh Vidhyanagar, Anand, India

Received 30 May 2011; Accepted 14 July 2011

Academic Editor: Mohamed Abdel-Rehim

Copyright © 2011 Zarna R. Dedania et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of the current study was to develop a validated stability-indicating assay method (SIAM) for risperidone after subjecting it to forced decomposition under hydrolysis, oxidation, photolysis, and thermal stress conditions. The liquid chromatographic separation was achieved isocratically on a symmetry C18 column (5 μm size, 250 mm × 4.6 mm i.d.) using a mobile phase containing methanol: acetonitrile (80 : 20, v/v) at a flow rate of 1 mL/min and UV detection at 280 nm. Retention time of risperidone was found to be 3 . 3 5 ± 0 . 0 1 . The method was linear over the concentration range of 10–60 μg/mL ( 𝑟 2 = 0 . 9 9 8 ) with a limit of detection and quantitation of 1.79 and 5.44 μg/mL, respectively. The method has the requisite accuracy, specificity, sensitivity, and precision to assay risperidone in bulk form and pharmaceutical dosage forms. Degradation products resulting from the stress studies did not interfere with the detection of Risperidone, and the assay is thus stability indicating.