Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations

Table 6

Accuracy assessment by recovery experiments.

Method	Tablet studied	FMT in tableta	Pure FMT addeda	Total found^a	Pure FMT recoveredb; percent ± SD
Titrimetry; method A	Topcid 20	3.0	1.5	4.52	101.3
		3.0	3.0	5.97	99.0
		3.0	4.5	7.40	97.78
Method B	Topcid 20	2.0	1.0	2.99	99.0
		2.0	2.0	4.05	102.5
		2.0	3.0	4.97	98.89
Spectrophotometry; method C	Topcid 20	1.5	0.75	2.27	102.7
		1.5	1.5	3.04	103.1
		1.5	2.25	3.81	102.7
Method D	Topcid 20	1.2	0.6	1.82	103.3
		1.2	1.2	2.43	102.5
		1.2	1.8	3.07	103.9

amg in titrimetry and 𝜇g mL⁻¹  in spectrophotometry.
bMean value of three measurements.