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International Journal of Analytical Chemistry
Volume 2011, Article ID 680902, 6 pages
http://dx.doi.org/10.1155/2011/680902
Research Article

Application of Certain π-Acceptors for the Spectrophotometric Determination of Alendronate Sodium in Pharmaceutical Bulk and Dosage Forms

1Analytical Laboratory, Bio Fine Pharmaceuticals, 74 Industrial Estate, Multan 60900, Pakistan
2Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan

Received 11 January 2011; Revised 1 May 2011; Accepted 1 May 2011

Academic Editor: Mohamed Abdel-Rehim

Copyright © 2011 Asad Raza and Muhammad Zia-ul-Haq. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two simple, fast, and accurate spectrophotometric methods for the determination of alendronate sodium are described. The methods are based on charge-transfer complex formation of the drug with two π-electron acceptors 7,7,7,8-tetracyanoquinodimethane (TCNQ) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in acetonitrile and methanol medium. The methods are followed spectrophotometrically by measuring the maximum absorbance at 840 nm and 465 nm, respectively. Under the optimized experimental conditions, the calibration curves showed a linear relationship over the concentration ranges of 2–10 μg mL−1 and 2–12 μg mL−1, respectively. The optimal reactions conditions values such as the reagent concentration, heating time, and stability of reaction product were determined. No significant difference was obtained between the results of newly proposed methods and the B.P. Titrimetric procedures. The charge transfer approach using TCNQ and DDQ procedures described in this paper is simple, fast, accurate, precise, and extraction-free.