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International Journal of Analytical Chemistry
Volume 2012 (2012), Article ID 508945, 7 pages
Research Article

Preliminary Assessment of the Chemical Stability of Dried Extracts from Guazuma ulmifolia Lam. (Sterculiaceae)

1Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Estadual de Maringá, Avenida Colombo, 5790, 87020-900 Maringá, PR, Brazil
2Student of Pharmacy, Universidade Estadual de Maringá, Avenida Colombo, 5790, 87020-900 Maringá, PR, Brazil
3Departamento de Fisiologia, Universidade Federal de Sergipe, Avenida Marechal Rondon, s/n, Cidade Universitária, 49100-000 São Cristóvão, SE, Brazil

Received 29 August 2011; Accepted 29 September 2011

Academic Editor: Ricardo Vessecchi

Copyright © 2012 Gisely C. Lopes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report the results of a preliminary estimation of the stability of the dried extract from bark of Guazuma ulmifolia Lam. (“Mutamba”), with and without added colloidal silicon dioxide (CSD). The physical and chemical properties and the compatibility of CSD in the extract were evaluated for 21 days of storage under stress conditions of temperature (45±2°C) and humidity (75±5%). Thermogravimetry (TG) was supplemented using selective high-performance liquid chromatography (HPLC) for determination of stability of the characteristic constituents (chemical markers), namely, procyanidin B2 (PB2) and epicatechin (EP). The results showed that PB2 is an appropriate compound to be used as a chemical marker in the quality control of dried extracts of G. ulmifolia. The stress study showed that there was no significant difference between the two formulations. However, considering the TG data and the high temperatures involved, the results suggest that CSD increases the stability of the dried extract of G. ulmifolia.