Research Article

Quantification of Niacin and Its Metabolite Nicotinuric Acid in Human Plasma by LC-MS/MS: Application to a Clinical Trial of a Fixed Dose Combination Tablet of Niacin Extended-Release/Simvastatin (500 mg/10 mg) in Healthy Chinese Volunteers

Table 4

The main pharmacokinetic parameters for NA and NUA after single oral doses of Niacin extended-release/Simvastatin to healthy volunteers (mean ± S.D., ).

1 tablet2 tablets3 tablets
NANUANANUANANUA

(μg·h/mL)0.3846 ± 0.19172.151 ± 1.3621.538 ± 0.95705.396 ± 3.2156.021 ± 6.57910.21 ± 7.076
(μg·h/mL)0.5176 ± 0.22652.181 ± 1.3681.719 ± 0.92305.478 ± 3.2496.097 ± 6.55510.25 ± 7.091
(h)8.80 ± 8.491.70 ± 0.8017.33 ± 8.682.55 ± 1.265.40 ± 4.572.72 ± 1.83
(1/h)0.19 ± 0.200.53 ± 0.310.43 ± 0.690.33 ± 0.140.27 ± 0.250.33 ± 0.15
(h)5.37 ± 1.962.91 ± 0.744.40 ± 2.213.60 ± 1.323.65 ± 1.333.79 ± 1.11
(μg/mL)0.1598 ± 0.12530.8360 ± 0.39890.9040 ± 0.48701.628 ± 0.63602.476 ± 1.4312.794 ± 1.038
(h)2.94 ± 2.632.06 ± 1.601.82 ± 1.693.03 ± 2.192.42 ± 1.642.33 ± 1.05
(L/h)1271 ± 850.0287.8 ± 128.2744.0 ± 356.0224.8 ± 91.90526.0 ± 421.0189.3 ± 94.20
(×103 L)13.71 ± 11.600.6490 ± 0.33807.649 ± 9.3240.8210 ± 0.52305.199 ± 6.6510.6960 ± 0.4580