Research Article
Stability-Indicating Assay for the Determination of Pentobarbital Sodium in Liquid Formulations
Table 2
Forced degradations studies.
| Stress conditions | % remaining | % degradation | Retention time of degraded products |
| Acidic stress (1 N HCl, 50°C, 1 h) | 102.2 | — | 0.0 | High acidic stress (12 N HCl, 50°C, 48 h) | 31.8 | 68.2 | 0.0 | Alkaline stress (1 N NaOH, 50°C, 1 h) | 98.4 | 1.6 | 0.0 | High alkaline stress (10 N NaOH, 50°C, 48 h) | 89.8 | 10.2 | 1.46, 1.81 | Oxidative stress (3%, 50°C, 48 h) | 50.9 | 49.1 | 1.44 | Thermal stress (50°C, 5 days) | 89.4 | 10.6 | 0.0 | High thermal stress (100°C, 1 h) | 19.9 | 80.1 | 0.0 | Direct sunlight (48 h) | 95.1 | 4.9 | 0.0 | Aqueous stability (after 21 days) | 99.7 | 0.3 | 0.0 |
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