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International Journal of Analytical Chemistry
Volume 2015, Article ID 796249, 11 pages
Research Article

Sample Preparation and Extraction in Small Sample Volumes Suitable for Pediatric Clinical Studies: Challenges, Advances, and Experiences of a Bioanalytical HPLC-MS/MS Method Validation Using Enalapril and Enalaprilat

Institute of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University, 40225 Düsseldorf, Germany

Received 31 October 2014; Revised 5 February 2015; Accepted 5 February 2015

Academic Editor: Mohamed Abdel-Rehim

Copyright © 2015 Bjoern B. Burckhardt and Stephanie Laeer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [3 citations]

The following is the list of published articles that have cited the current article.

  • Andrei Medvedovici, Elena Bacalum, and Victor David, “Sample preparation for large-scale bioanalytical studies based on liquid chromatographic techniques,” Biomedical Chromatography, pp. e4137, 2017. View at Publisher · View at Google Scholar
  • Ciplea Agnes Maria, Laeer Stephanie, and Burckhardt Bjoern Bengt, “A feasibility study prior to an international multicentre paediatric study to assess pharmacokinetic/pharmacodynamic sampling and sample preparation procedures, logistics and bioanalysis,” Contemporary Clinical Trials Communications, 2018. View at Publisher · View at Google Scholar
  • Mohsin Ali, Stephanie Läer, and Bjoern B Burckhardt, “LC–MS/MS method for screening of intoxication and drug adherence of angiotensin-converting enzyme inhibitors in plasma,” Bioanalysis, 2018. View at Publisher · View at Google Scholar