Development and Validation of HPLC Method for the Simultaneous Determination of Five Food Additives and Caffeine in Soft Drinks

Figure 2

Response surface plots for BBD: (a) pH () versus flow rate () (mobile phase ratio: 95%); (b) pH () versus mobile phase ratio () (flow rate: 1.0 mL/min); (c) flow rate () versus mobile phase ratio () (pH: 6.0).

(a)

(b)

(c)