New Modified UPLC/Tandem Mass Spectrometry Method for Determination of Risperidone and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Dose-Dependent Pharmacokinetic Study in Sprague-Dawley Rats

Table 1

Mass optimization parameter for RIS, 9-OH-RIS, and OLA.

Parameters	RIS	9-OH-RIS	IS
Cone voltage (V)	45	45	40
Collision energy (eV)	30	25	20
The collision gas (argon) flow rate (ml/min)	0.1	0.1	0.1
Nitrogen flow rate	600 L/h	600 L/h	600 L/h