New Modified UPLC/Tandem Mass Spectrometry Method for Determination of Risperidone and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Dose-Dependent Pharmacokinetic Study in Sprague-Dawley Rats

Table 2

Intra- and interday precision and accuracy of RIS in rat plasma.

Theoretical conc. (ng/mL)	Intraday			Interday
	Measured conc. (ng/mL); (mean ± SD)	Precision (CV%)	Accuracy (%)	Measured conc. (ng/mL); (mean ± SD)	Precision; (CV%)	Accuracy (%)
0.2	0.21 ± 0.004	7.30	105.00	0.23 ± 0.01	8.33	115.0
2	1.99 ± 0.05	3.77	99.50	1.97 ± 0.13	5.69	98.50
20	19.19 ± 0.01	5.88	95.95	20.1 ± 2.70	3.99	100.50
400	395 ± .020	7.57	98.75	398 ± 1.35	7.15	99.50