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International Journal of Analytical Chemistry
Volume 2017 (2017), Article ID 1728414, 5 pages
Research Article

GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form

1Department of Pharmacy, Faculty of Medicine & Health Sciences, An Najah National University, Nablus, State of Palestine
2R&D Department, Avalon Pharma, Riyadh, Saudi Arabia

Correspondence should be addressed to Murad N. Abualhasan; ude.hajan@nasahlauba_m

Received 26 November 2016; Revised 22 January 2017; Accepted 1 February 2017; Published 6 March 2017

Academic Editor: Ashish Rawson

Copyright © 2017 Murad N. Abualhasan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Menthol is widely used as a fragrance and flavor in the food and cosmetic industries. It is also used in the medical and pharmaceutical fields for its various biological effects. Gas chromatography (GC) is considered to be a sensitive method for the analysis of menthol. GC chromatographic separation was developed using capillary column (VF-624) and a flame ionization detector (FID). The method was validated as per ICH guidelines for various parameters such as precision, linearity, accuracy, solution stability, robustness, limit of detection, and quantification. The tested validation parameters were found to be within acceptable limits. The method was successfully applied for the quantification of menthol in suppositories formulations. Quality control departments and official pharmacopeias can use our developed method in the analysis of menthol in pharmaceutical dosage formulation and raw material.