Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Table 4

Retention times, calibration curve linearity, LOD, and LOQ.

Antipsychotics	Rt(min)	Therapeutic range (ng/ml)	Concentration range (ng/ml)	Regression equations	R^2	LOD (ng/ml)	LOQ (ng/ml)
Chlorpromazine	2.45±0.04	30-300	15-450	y = 0.06762x +	0.99965	3.95 (0.53)	13.17 (1.70)
			(15, 30, 75, 150, 300 and 450)	0.17059
Haloperidol	5.38±0.05	5-17	2-60	y = 0.18126x +	0.99902	0.36 (0.11)	1.19 (0.49)
			(2, 4, 10, 20, 40 and 60)	0.06470
Levomepromazine	5.62±0.08	15-60	5-150	y = 0.03452x +	0.99927	1.50 (0.80)	4.99 (2.26)
			(5, 10, 25, 50, 100 and 150)	0.01757
Olanzapine	2.34±0.05	20-80	5-150	y = 0.03241x -	0.99915	0.87 (0.33)	2.89 (1.01)
			(5, 10, 25, 50, 100 and 150)	0.01622
Risperidone	3.88±0.05	20-60	5-150	y = 0.08304x +	0.99975	1.378 (0.15)	4.59 (0.52)
			(5, 10, 25, 50, 100 and 150)	0.01389
Sulpiride	5.07±0.05	200-1,000	40-1,200	y = 0.04711x +	0.99984	2.11 (0.41)	7.04 (1.82)
			(40, 80, 200, 400, 800 and 1,200)	0.05818

(): LOD and LOQ using S/N approach.