Research Article
Development of a Robust UPLC Method for Simultaneous Determination of a Novel Combination of Sofosbuvir and Daclatasvir in Human Plasma: Clinical Application to Therapeutic Drug Monitoring
Figure 2
Typical UPLC chromatograms of (a) drug-free human plasma; (b) blank plasma spiked with SF and DC at LLOQ, (c) blank plasma spiked with SF and DC at ULOQ, and (d) plasma sample from a volunteer 0.5 h after administration of DarvoniĀ® (400 mg of SF/60 mg of DC).
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