Development and Validation of an HPLC-MS/MS Method for Rapid Simultaneous Determination of Cefprozil Diastereomers in Human Plasma

Table 2

Assessment of recovery and matrix effect for cis- and trans-cefprozil (n = 6).

Compound	Concentration; (μg/mL)	Recovery (%); Mean ± SD	IS normalized matrix effect
			Mean (%)	CV (%)
Cis-cefprozil	0.05	100.3±5.3	93.7	3.0
	4.1	96.2±3.0	NA	NA
	12.4	99.1±7.7	92.6	3.8
Trans-cefprozil	0.025	102.9±4.2	92.4	7.7
	0.445	96.9±4.3	NA	NA
	1.33	105.1±2.8	91.6	6.0

SD: standard deviation; CV: coefficient of variance; NA: not available.