Comprehensive Assessment of Degradation Behavior of Simvastatin by UHPLC/MS Method, Employing Experimental Design Methodology

Figure 5

3D response surface plots showing the formation of impurity RRT 1.16 under various conditions: (a) acid degradation; (b) alkali degradation; (c) oxidative degradation; and (d) thermal degradation. Color change from blue to red represents increasing degradation (minmax).

(a)

(b)

(c)

(d)