Research Article
Comprehensive Assessment of Degradation Behavior of Simvastatin by UHPLC/MS Method, Employing Experimental Design Methodology
Table 3
Experimental conditions and results from full factorial design for acid, alkali, oxidative, and thermal degradation.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
: stressor strength 0.01 M and 0.1 M HCl/NaOH or 3% and 30% H2O2 for hydrolysis and oxidative degradation respectable; : temperature 25°C and 40°C; : time 15 and 45 minutes; : temperature: 80°C and 105°C; : time 180 and 300 minutes; : amount of total impurities (%);: amount of impurity with RRT 1.16 (%); and : amount of impurity A (%). The high level of each factor was considered as “+" and low level as “−". |