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International Journal of Analytical Chemistry
Volume 2019, Article ID 3987417, 7 pages
https://doi.org/10.1155/2019/3987417
Research Article

Stability of Propofol (2,6-Diisopropylphenol) in Thermal Desorption Tubes during Air Transport

1CBR-Center of Breath Research, Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center and Saarland University Faculty of Medicine, 66424 Homburg/Saar, Germany
2Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA

Correspondence should be addressed to Felix Maurer; ue.sku@reruam.xilef

Received 5 March 2019; Accepted 7 April 2019; Published 2 May 2019

Academic Editor: Charles L. Wilkins

Copyright © 2019 Felix Maurer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. R. Harrison, A. D. J. Critchley, C. A. Mayhew, and J. M. Thompson, “Real-time breath monitoring of propofol and its volatile metabolites during surgery using a novel mass spectrometric technique: A feasibility study,” British Journal of Anaesthesia, vol. 91, no. 6, pp. 797–799, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. W. Miekisch, P. Fuchs, S. Kamysek, C. Neumann, and J. K. Schubert, “Assessment of propofol concentrations in human breath and blood by means of HS-SPME-GC-MS,” Clinica Chimica Acta, vol. 395, no. 1-2, pp. 32–37, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Liu, Y. Gong, C. Wang et al., “Online breath analysis of propofol during anesthesia: Clinical application of membrane inlet-ion mobility spectrometry,” Acta Anaesthesiologica Scandinavica, vol. 59, no. 3, pp. 319–328, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Kreuer, A. Hauschild, T. Fink, J. I. Baumbach, S. Maddula, and T. Volk, “Two different approaches for pharmacokinetic modeling of exhaled drug concentrations,” Scientific Reports, vol. 4, p. 5423, 2014. View at Google Scholar · View at Scopus
  5. M. Grossherr, A. Hengstenberg, T. Meier, L. Dibbelt, K. Gerlach, and H. Gehring, “Discontinuous monitoring of propofol concentrations in expired alveolar gas and in arterial and venous plasma during artificial ventilation,” Anesthesiology, vol. 104, no. 4, pp. 786–790, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Maurer, M. Geiger, T. Volk, D. I. Sessler, and S. Kreuer, “Validation of liquid and gaseous calibration techniques for quantification of propofol in breath with sorbent tube Thermal Desorption System GC–MS,” Journal of Pharmaceutical and Biomedical Analysis, vol. 143, pp. 116–122, 2017. View at Publisher · View at Google Scholar · View at Scopus
  7. W. Vautz and M. Schmäh, “HovaCAL®-a generator for multi-component humid calibration gases,” International Journal for Ion Mobility Spectrometry, vol. 12, no. 4, pp. 139–147, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. P. A. Clausen and P. Wolkoff, “Degradation products of Tenax TA formed during sampling and thermal desorption analysis: Indicators of reactive species indoors,” Atmospheric Environment, vol. 31, no. 5, pp. 715–725, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Berchtold, M. Bosilkovska, Y. Daali, B. Walder, and R. Zenobi, “Real-time monitoring of exhaled drugs by mass spectrometry,” Mass Spectrometry Reviews, vol. 33, no. 5, pp. 394–413, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. S. W. Harshman, N. Mani, B. A. Geier et al., “Storage stability of exhaled breath on Tenax TA,” Journal of Breath Research, vol. 10, no. 4, 2016. View at Google Scholar · View at Scopus