Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution Studies

<div>Plasma concentration-time profiles of brigatinib and brigatinib-analog following single oral administration of 5 mg/kg of brigatinib and brigatinib-analog in male SD rats (<i>n</i> = 6).</div>

International Journal of Analytical Chemistry

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Figure 3: Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution Studies 

Figure 3 | Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution Studies 