Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-UV

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2"><i>U</i><sub><i>i</i></sub></td><td class="align_center" rowspan="2">Factor</td><td class="align_center" colspan="2">Value</td></tr><tr class="thead"><td class="align_center">−1</td><td class="align_center">+1</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left"><i>U</i><sub>1</sub></td><td class="align_center">% ACN</td><td class="align_center">25</td><td class="align_center">40</td></tr><tr><td class="align_left"><i>U</i><sub>2</sub></td><td class="align_center">Mobile-phase pH</td><td class="align_center">2</td><td class="align_center">7</td></tr><tr><td class="align_left"><i>U</i><sub>3</sub></td><td class="align_center">Buffer nature</td><td class="align_center">Phosphate</td><td class="align_center">Perchlorate</td></tr><tr><td class="align_left"><i>U</i><sub>4</sub></td><td class="align_center">Temperature</td><td class="align_center">30</td><td class="align_center">40</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Investigated variables and their levels studied in the 2<sup>4</sup> factorial design.</div>

International Journal of Analytical Chemistry

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Table 1

Table 1: Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-UV 

Table 1 | Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-UV 