Application of Factorial and Doehlert Designs for the Optimization of the Simultaneous Separation and Determination of Antimigraine Drugs in Pharmaceutical Formulations by RP-HPLC-UV

Table 8

Content of industrial pharmaceutical forms with respect to the label amount claimed.

Sample	Compounds	Label content	Norms (%)	Found	Recovery (%)
Zomig tablets	Zol	2.5 mg/tablet	100.0 ± 5.0	2.44 mg/tablet	97.45
Naramig tablets	Nara	2.5 mg/tablet	100.0 ± 5.0	2.49 mg/tablet	99.87
Ikaran LP tablets	DHE	5 mg/tablet	100.0 ± 5.0	5.13 mg/tablet	102.60
Pizofen tablets; Pizofen syrup	Pizo	0.5 mg/tablet; 0.25 mg/5 mL	100.0 ± 5.0; 100.0 ± 5.0	0.49 mg/tablet; 0.24 mg/5 mL	98.04; 98.24
Tefanyl tablets	Keto	1.0 mg/tablet	100.0 ± 5.0	0.99 mg/tablet	98.61