International Journal of Analytical Chemistry / 2020 / Article / Tab 3

Research Article

Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application

Table 3

The stability of enasidenib in rat plasma (n = 6).

CompoundsSpiked (ng/mL)Room temperature, 12 hAutosampler 4°C, 12 hThree freeze-thaw−20°C, 4 weeks
RSD (%)RE (%)RSD (%)RE (%)RSD (%)RE (%)RSD (%)RE (%)

Enasidenib2.54.51−0.765.94−3.456.790.478.69−1.94
4005.15−0.553.351.965.480.764.081.07
8002.242.732.483.751.352.382.941.79

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