International Journal of Analytical Chemistry / 2020 / Article / Tab 2

Research Article

Establishment and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Tigecycline in Critically Ill Patients

Table 2

Matrix effect of TGC in various plasma matrices.

Nominal concentration (ng/ml)Normalized plasmaHemolyzed plasmaHyperlipidemic plasma
Matrix effects (%)IS-normalized matrix effects (%)Matrix effects (%)IS-normalized matrix effects (%)Matrix effects (%)IS-normalized matrix effects (%)

150209 ± 11.0103 ± 6.9209 ± 1.4104 ± 5.6200 ± 5.295 ± 3.2
750182 ± 1.987 ± 5.2193 ± 9.396 ± 6.0179 ± 1.493 ± 3.8
3800149 ± 1.695 ± 2.0152 ± 3.495 ± 2.1150 ± 1.598 ± 2.1
CV (%)14.58.513.86.012.04.0

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