Pharmacokinetics of Lusutrombopag, a Novel Thrombopoietin Receptor Agonist, in Rats by UPLC-MS/MS

Table 3

Primary pharmacokinetic parameters after oral administration of lusutrombopag in rats (n = 6).

Parameter	Unit	Oral administration (n = 6)
AUC(0–t)	μg/L·h	30739.23 ± 6067.41
AUC(0–∞)	μg/L·h	30864.05 ± 6204.74
MRT(0–t)	h	12.30 ± 0.88
MRT(0–∞)	h	12.50 ± 0.97
t 1/2z	h	6.57 ± 1.37
T max	h	5.17 ± 1.84
Vz/F	L/kg	3.08 ± 0.30
CLz/F	L/h/kg	0.34 ± 0.07
C max	μg/L	2187.22 ± 279.56